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Recombination and mammalian genome evolution

Adam Eyre-Walker
Published 22 June 1993.DOI: 10.1098/rspb.1993.0071
Adam Eyre-Walker
Institute of Cell Animal and Population Biology, University of Edinburgh, Edinburgh, U. K.
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Abstract

Several lines of evidence are presented which suggest that sequence G + C content and recombination frequency are related in mammals: (i) chromosome G + C content is positively correlated to chiasmata density; (ii) the non-pairing region of the Y chromosome has one of the lowest G + C contents of any chromosomal segment; (iii) a reduction in the rate of recombination at several loci is mirrored by a decrease in G + C content; and (iv) when compared with humans, mice have a lower variance in chiasmata density which is reflected in a lower variance in G + C content. The observed relation between recombination frequency and sequence G + C content provides an elegant explanation of why gene density is higher in G + C rich isochores than in other parts of the genome, and why long interspersed elements (lines) are exclusive to G + C poor isochores. However, the cause of the relation is as yet unknown. Several possibilities are considered, including gene conversion.

Footnotes

  • This text was harvested from a scanned image of the original document using optical character recognition (OCR) software. As such, it may contain errors. Please contact the Royal Society if you find an error you would like to see corrected. Mathematical notations produced through Infty OCR.

  • Received March 8, 1993.
  • Accepted April 19, 1993.
  • Scanned images copyright © 2017, Royal Society

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22 June 1993
Volume 252, issue 1335
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Recombination and mammalian genome evolution
Adam Eyre-Walker
Proc. R. Soc. Lond. B 1993 252 237-243; DOI: 10.1098/rspb.1993.0071. Published 22 June 1993
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Recombination and mammalian genome evolution

Adam Eyre-Walker
Proc. R. Soc. Lond. B 1993 252 237-243; DOI: 10.1098/rspb.1993.0071. Published 22 June 1993

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