Royal Society Publishing

The Wellcome Foundation Lecture, 1994. The Fetal Origins of Adult Disease

D. J. P. Barker


Recent findings suggest that many human fetuses have to adapt to a limited supply of nutrients and in doing so they permanently change their physiology and metabolism. These `programmed' changes may be the origins of a number of diseases in later life, including coronary heart disease and the related disorders: stroke, diabetes and hypertension.